MELAS or more
نویسندگان
چکیده
منابع مشابه
More force or more smart?
In this issue of Blood, Palumbo and colleagues describe a trial in newly diagnosed patients with MM who are eligible for high-dose therapy. They compare 2 different dosages of double high-dose melphalan (100 mg/m2 vs 200 mg/m2) followed by autologous stem cell transplantation.1 It is concluded that MEL200 is superior to MEL100 with respect to progression-free survival and time to progression, b...
متن کاملMELAS: A Multigenerational Impact of the MTTL1 A3243G MELAS Mutation.
BACKGROUND the maternally inherited MTTL1 A3243G mutation in the mitochondrial genome causes MelaS (Mitochondrial encephalopathy lactic acidosis with Stroke-like episodes), a condition that is multisystemic but affects primarily the nervous system. Significant intra-familial variation in phenotype and severity of disease is well recognized. METHODS retrospective and ongoing study of an extend...
متن کاملPhenotypic heterogeneity of MELAS☆☆☆
With interest we read the article by Dvorakova et al. about 50 Czech patients carrying the m.3243ANG mutation [1]. It raises questions and concerns. Since MELAS is a progressive disease, we should be informed about the long-term follow-up findings in the 50 mutation carriers. How many of the 17 patients without clinical manifestations at inclusion developed MELAS during follow-up? How many of t...
متن کاملCerebral hyperemia in MELAS.
BACKGROUND The pathophysiology of stroke-like episodes in MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is uncertain. CASE DESCRIPTION We studied a 24-year-old man with MELAS who had fluent aphasia and right hemianopia. Magnetic resonance imaging and computed tomography showed a large infarction in the parietal, temporal, and occipital lobes. We performed ...
متن کاملArrhythmias in MELAS syndrome
With interest we read the article by Thomas et al. about a 44 year old female with MELAS syndrome due to the m.3243ANG mutation, which manifested cardiologically as hypertrophic cardiomyopathy and episodes of supraventricular tachycardia requiring atenolol [1]. We have the following comments and concerns. MELAS may be associated with sudden cardiac death [2]. Did the authors consider implantati...
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ژورنال
عنوان ژورنال: Arquivos de Neuro-Psiquiatria
سال: 2016
ISSN: 0004-282X
DOI: 10.1590/0004-282x20160022